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Contact UsThe company focuses on the research, development, production, and sales of chemical raw materials and their formulations. All products have passed national GMP certification, and core products have successively passed official pharmaceutical regulatory certifications from multiple countries, including the EU EDQM, US FDA, Japanese PMDA, and South Korean MFDS. Following its successful listing on the Shenzhen Stock Exchange's ChiNext board on April 4, 2023, Keyuan Pharmaceutical has entered a phase of rapid development driven by both digital intelligence and capital, with its business spanning dozens of countries and regions worldwide.
Continuous flow technology
Continuous Flow Technology Platform: Intelligent and Efficient, Reshaping Production Modes
——A Chemical Revolution in Microchannels
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Platform Overview Koyuan Pharmaceutical's continuous flow technology platform uses microreactor technology as its core, integrating intelligent control, process intensification, and automated systems to create a full-process continuous flow solution from laboratory to industrialization. The platform focuses on the pharmaceutical, fine chemical, and new materials industries, using high-throughput, high-safety, and highly controllable continuous manufacturing processes to help companies achieve green and intelligent production, and to promote the industry's transformation and upgrading from traditional batch reactions to continuous flow intelligent manufacturing. |
Platform Value and Vision Technology Empowerment: Possessing the "full-process development capability" from process development and equipment selection to pilot-scale expansion, helping companies complete technology transformation in 3-6 months. Safety and Efficiency: Eliminating batch differences, improving product consistency, and reducing production costs by 30%-50%. Sustainable Development: Promoting green manufacturing with continuous flow technology to reduce resource waste and environmental pollution. Open Collaboration: Jointly building an intelligent continuous manufacturing ecosystem with upstream and downstream companies and research institutions to lead industry transformation. |
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Core Technologies and Advantages 1. Microchannel Reactor Technology Efficient Mass and Heat Transfer: Micrometer-scale reaction channels achieve millisecond-level reaction control, improving reaction efficiency (e.g., temperature control accuracy of strongly exothermic reactions reaches ±1℃). High Safety: Suitable for high-risk processes (such as nitration and diazotization reactions), significantly reducing the risk of explosion and meeting GMP and REACH regulations. 2. Intelligent Control and Automation Full-process Digital Twin System: Using AI algorithms to simulate reaction pathways, optimize process parameters, and shorten the R&D cycle by more than 50%. Modular Design: Supports seamless switching from milligram-level to ton-level production, flexibly adapting to different scale requirements. 3. Green Process Innovation Dual Reduction of Solvent and Energy Consumption: Reducing solvent use by more than 80% through online separation and catalyst recycling technologies, in line with green chemistry principles. Zero-Emission Process Development: Achieving resource utilization of by-products to contribute to carbon neutrality goals. 4. Industry-Academia-Research Collaboration In-depth cooperation with universities and enterprises such as Kelun-Bio and Taizhou Puyu to overcome the bottlenecks of continuous flow technology in complex molecular synthesis. The core technologies cover the entire process of continuous flow process development, equipment selection, and industrial production. |
Application Fields and Achievements 1. Drug R&D and Production API Synthesis: Developing continuous flow processes for key intermediates of anti-tumor drugs and antihypertensive drugs, increasing yield to over 95% and reducing impurities by 50%. CMC Submission Support: Providing innovative pharmaceutical companies with continuous flow process development and scaling services that meet FDA and NMPA requirements. 2. Green Fine Chemicals Functional Material Preparation: Producing high-purity liquid crystal monomers and photoinitiators through continuous flow processes, with purity reaching 99.9%. Specialty Chemicals: Developing safe continuous flow synthesis pathways for hazardous chemicals (such as azo compounds) to achieve industrialization. 3. Environmental Protection and Energy Pollutant Degradation: Continuous flow catalytic oxidation technology treats refractory organic matter in industrial wastewater, with a COD removal rate of over 95%. Biofuel Synthesis: Achieving continuous production of fatty acid methyl esters (FAME), reducing energy consumption by 40% |
Address: No. 26, Keyuan Street, Shanghe County, Jinan City, Shandong Province
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