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Contact UsThe company focuses on the research, development, production, and sales of chemical raw materials and their formulations. All products have passed national GMP certification, and core products have successively passed official pharmaceutical regulatory certifications from multiple countries, including the EU EDQM, US FDA, Japanese PMDA, and South Korean MFDS. Following its successful listing on the Shenzhen Stock Exchange's ChiNext board on April 4, 2023, Keyuan Pharmaceutical has entered a phase of rapid development driven by both digital intelligence and capital, with its business spanning dozens of countries and regions worldwide.
Chiral catalysis technology
Chiral Catalysis Technology Platform: Precision Creation, Defining the Future
——Taking molecular selection to the extreme
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Platform Overview Koyuan Pharmaceutical's chiral catalysis technology platform takes highly efficient asymmetric catalysis as its core, integrating computational simulation, high-throughput screening, and process optimization technologies to provide high-selectivity, high-yield chiral compound synthesis solutions for the pharmaceutical, fine chemical, and new materials industries. The platform is committed to solving pain points such as low optical purity, complex steps, and high energy consumption in traditional synthesis through green and economical chiral catalysis technology, helping to achieve precise molecular creation and green sustainable production. |
Platform Value and Vision Technology Empowerment: Possessing the "full chain" capability from catalyst screening and process development to industrial scale-up, helping projects achieve technology transformation in 6-12 months. Cost and Efficiency Improvement: Reducing separation and purification processes, lowering production costs by 40%-60%; shortening R&D cycles, and accelerating product launch. Green Manufacturing: Through atom-economic reactions and the application of renewable raw materials, helping customers achieve ESG goals. Open Ecosystem: Jointly building a chiral catalysis technology ecosystem with upstream and downstream enterprises and research institutions to promote industry standardization and high-quality development. |
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Core Technologies and Advantages 1. Highly Efficient Asymmetric Catalysis System Independent Catalyst Design: Developing metal catalysts (such as iridium, palladium, and rhodium-based) and small organic molecule catalysts, covering key reaction types such as hydrogenation, oxidation, and cross-coupling. High Enantioselectivity: Achieving over 99% ee (enantiomeric excess), reducing separation and purification steps in a single synthesis, and lowering production costs. 2. Intelligent Screening and Process Optimization AI-Assisted Catalyst Design: Using machine learning to predict catalyst activity and selectivity, shortening the development cycle by over 60%. High-Throughput Experimental Platform: Rapidly screening the optimal reaction conditions (temperature, solvent, ligand, etc.), adapting to the needs of scaling up from the laboratory to industrialization. 3. Green and Sustainable Atom-Economic Design: Reducing byproduct generation and lowering waste disposal costs. Application of Renewable Resources: Developing substrate sources based on biomass raw materials to promote carbon-neutral pathways. 4. Deep Integration of Industry, Academia, and Research In-depth cooperation with Tsinghua University, Jiangnan University, and Jinan University in the research and development of chiral catalysis technology to overcome the challenges of synthesizing complex chiral drug molecules. The core technologies cover the entire process of catalyst design, process development, and process safety evaluation. |
Application Fields and Achievements 1. Innovative Drug Development Chiral Drug Intermediates: Developing key intermediates for anti-tumor drugs (such as taxanes) and hypoglycemic drugs (such as DPP-4 inhibitors), with optical purity reaching 99.9%. Accelerated CMC Development: Providing chiral process routes that meet international submission standards for innovative pharmaceutical companies, shortening the IND/ANDA submission cycle. 2. High-End Chemical Manufacturing Pesticides and Veterinary Drugs: Achieving highly efficient synthesis of insecticides and plant growth regulators, with yields exceeding 95%. Functional Material Monomers: Developing optically pure liquid crystal monomers and optically active polymer monomers to meet the needs of the display and electronics industries. 3. Biopharmaceuticals and Enzyme Catalysis Biocatalytic Processes: Using enzymatic catalysis to achieve green synthesis of amino acids and chiral alcohols, reducing environmental burden. Dynamic Kinetic Resolution: Solving the production bottleneck of difficult-to-separate chiral compounds, achieving highly efficient "one-pot" conversion. |
Address: No. 26, Keyuan Street, Shanghe County, Jinan City, Shandong Province
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