Keyuan Pharmaceutical Keyuan Pharmaceutical

Stock Code: 301281
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Technology Platform

Nitration reaction technology

Hydrogenation reaction technology

Sulfonation reaction technology

Fluorination reaction technology

Chiral catalysis technology

Enzyme catalysis technology

Continuous flow technology

Enzyme catalysis technology

Enzyme Catalysis Technology Platform: Green Biocatalysis, Driving Sustainable Innovation
——Power of Nature, Catalyzing the Future

Platform Overview

Koyuan Pharmaceutical's enzyme catalysis technology platform uses biocatalysis as its core, combining synthetic biology, protein engineering, and enzyme molecular directed evolution technology to develop efficient, green, and sustainable enzyme catalysis solutions. The platform focuses on pharmaceutical intermediates, fine chemicals, and biofuels. Through a full-chain technology system of "enzyme design-optimization-industrial application", it achieves low-cost, high-selectivity, and environmentally friendly production paths, helping to achieve the "dual carbon" goals and green manufacturing transformation.

Platform Value and Vision

Green Transformation: Replacing traditional chemical processes with biocatalysis, reducing the use of toxic solvents by over 90%, and lowering carbon emissions.

Technology Empowerment: Providing end-to-end solutions from laboratory to industrialization, shortening product development cycles to 6-12 months.

Open Collaboration: Joining hands with universities, pharmaceutical companies, and chemical groups to build a green technology ecosystem and promote sustainable industry development.

Core Technologies and Advantages

1. Biocatalyst R&D Capabilities

High-efficiency enzyme engineering: Based on gene editing and protein structure optimization technology, directed evolution of industrial enzymes with high temperature resistance, organic solvent resistance, and high catalytic activity significantly improves reaction efficiency (e.g., conversion rate increased by over 300%).

Chiral enzyme catalysis: Developing enzymes for asymmetric synthesis, precisely controlling the configuration of chiral drug intermediates, and reducing byproducts and separation costs in traditional chemical synthesis.

2. Green Production Processes

Mild reaction conditions: Enzyme catalysis does not require high temperature and high pressure; efficient catalytic reactions can be achieved at normal temperature and pressure, reducing energy consumption and equipment costs.

Recyclable: Enzyme catalysts can be reused multiple times, reducing waste emissions and meeting clean production standards.

3. High-throughput Screening and AI-assisted Design

Enzyme library and high-throughput screening platform: Establishing a resource library containing various industrial enzymes, combined with AI-driven molecular dynamics simulation and machine learning algorithms, accelerates the directed evolution and functional optimization of enzymes.

Intelligent reactor: Developing a modular enzyme catalysis reaction system that supports multi-channel synchronous experiments to achieve precise control and rapid optimization of process parameters.

4. Industry-Academia-Research Collaboration and Innovation

Cooperating with top research institutions such as the Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, and Jiangnan University to overcome key technical bottlenecks such as enzyme stability and large-scale production.

Exclusive technology licensing: Through patent layout (such as enzyme immobilization technology patents, chiral selective catalyst patents), ensuring technological barriers and competitiveness.

Application Fields and Achievements

1. Pharmaceutical and Health Fields

Drug synthesis: Developing efficient enzyme catalytic pathways for key intermediates of anticancer drugs and hypoglycemic drugs, shortening synthesis steps, and reducing impurity risks.

Biomanufacturing: Using enzyme catalysis to produce amino acids, vitamins, and other nutritional chemicals, replacing traditional high-pollution chemical processes.

2. Green Chemical Engineering and New Materials

Degradable materials: Synthesizing polylactic acid (PLA) monomers through enzyme catalysis to promote the industrialization of bio-based plastics.

Fine chemicals: Developing biotransformation processes for fragrance and cosmetic raw materials to improve product purity and safety.

3. Environmental Governance and Energy

Pollutant degradation: Enzyme catalysis decomposes persistent organic pollutants (such as pesticide residues and toxic substances in industrial wastewater) to achieve environmental remediation.

Biofuels: Producing ethanol from cellulose through enzymatic hydrolysis to promote the large-scale production of bioenergy.

 

 

 

 

Enzyme catalysis technology